The investigation of antimicrobial activity of some s-substituted bis-1,2,4-triazole-3-thiones

New S-substituted 4-alkyl-5-((3-(pyridin-4-yl)-1H-1,2,4-triazole-5-yl)thio)methyl)-4H-1,2,4-triazole-3-thiol derivatives have been designed, synthesized and studied their antimicrobial activity on 11 standard Gram-positive Gram-negative microorganism strains. Their spectral physicochemical parameters were established using modern comprehensive methods of analysis, including 1 H NMR spectroscopy, GC-MS elemental analysis.It has found that compound 2a exhibits strong suppression 5 test strains (MBC = 15.6 µg/mL). Compound 4a showed moderate inhibition Salmonella pullorum , Escherichia coli O 2 enteritidis 31.25 µg/mL) 6a was sensitive toward ten tested bacteria at µg/mL concentration.